Single nucleotide polymorphisms of CTLA4 gene and their association with human cervical cancer.
- Author:
Li JIANG
1
;
Ruo-yu LUO
;
Wei ZHANG
;
Li-rong WANG
;
Fang WANG
;
Yan-xiang CHENG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Alleles; Antigens, CD; genetics; CTLA-4 Antigen; Case-Control Studies; Female; Gene Expression Regulation, Neoplastic; genetics; Genetic Predisposition to Disease; Genotype; Humans; Middle Aged; Polymorphism, Single Nucleotide; Uterine Cervical Neoplasms; genetics; Young Adult
- From: Chinese Journal of Medical Genetics 2011;28(3):313-317
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the association between single nucleotide polymorphisms (SNPs) of cytotoxic T-lymphocyte-associated protein 4 (CTLA4) gene and susceptibility to cervical cancer.
METHODSOne hundred patients and 100 healthy controls from Hubei province were genotyped for 20 polymorphic loci using Sequenom.
RESULTSThe frequency of rs11571316 G allele and rs5742909 T allele, which are localized in the promoter region, and rs11571319 A allele, which is downstream of the gene, were significantly higher in patients than in controls. Luciferase assay showed that, as the previously reported rs5742909 T allele, rs11571316 G allele could significantly increase the expression of the reporter gene.
CONCLUSIONSNPs in the promoter region of (CTLA4) gene might increase the susceptibility to cervical cancer by increasing (CTLA4) gene expression.
