Genetic polymorphism of the killer cell immunoglobulin-like receptor genes in the Inner Mongolian population.
- Author:
Bo JIANG
1
;
Ai-li WANG
;
Zhong JU
;
Yi-min SHEN
;
Xue-feng HE
;
Yong-hong ZHANG
;
Ri ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Asian Continental Ancestry Group; genetics; China; Genotype; Humans; Phylogeny; Polymorphism, Genetic; Receptors, KIR; genetics
- From: Chinese Journal of Medical Genetics 2011;28(3):336-340
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the killer cell immunoglobulin-like receptor (KIR) gene frequencies and genotypes distributions in the Inner Mongolian population.
METHODSNinety genomic DNA samples were extracted from blood samples of randomly chosen Mongolian individuals. Gene-specific PCR amplification was used to identify genes present or absent for 16 KIR loci. KIR genotype distributions were obtained and compared to that of 24 populations published in literatures using principal component analysis by SAS8.0 software. Genetic tree was constructed by the calculate Nei's genetic distance.
RESULTS(1) The frequency of KIR 2DL2, 2DS2 in Mongolian individual is higher than that in north Mongoloid and less than that in Caucasian. (2) Haplotype AA was identified in 37.78% of individuals, which is higher than that in north Mongoloid and lower than that in Caucasian. (3) Mongolian was considered between north Mongoloid and Caucasian by principal component and genetic tree analysis.
CONCLUSIONMongolian might be affected by the north Mongoloid and Caucasian, and showed intermediate between the two populations.
