Association of single nucleotide polymorphism on chromosome 12q24.31 with susceptibility to coronary artery disease.
- VernacularTitle:染色体12q24.31单核苷酸多态性与冠状动脉粥样硬化性心脏病遗传易感性的关联研究
- Author:
Wen-wen XIAO
1
;
Chuan-wei LI
;
Zhi ZENG
;
Rui LIU
;
Xian LI
;
Yu-cheng CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Base Sequence; Case-Control Studies; Chromosomes, Human, Pair 12; genetics; Coronary Artery Disease; blood; genetics; Female; Gene Frequency; Genetic Predisposition to Disease; genetics; Humans; Lipids; blood; Male; Polymorphism, Single Nucleotide; genetics
- From: Chinese Journal of Medical Genetics 2011;28(4):455-459
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo determine whether the single nucleotide polymorphism (SNP) on chromosome 12q24.31(rs2259816) is associated with coronary artery disease (CAD) in Han population of southwest China.
METHODSA case-control association study with 592 unrelated patients with coronary artery disease and 463 normal controls from Chinese Han population was performed. Genotype for the SNP on chromosome 12q24.31 (rs2259816) was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
RESULTSThe genotypes of AA, AC, CC were both detected in the coronary artery disease group and the control group. The frequencies of A allele were 49.5% in case group and 43.8% in control group, showing statistically significant difference(OR=1.129, 95%CI:1.029-1.239, P=0.010).
CONCLUSIONThe replication study showed that the genetic polymorphism in rs2259816 is associated with coronary artery disease in Han population of southwest China.
