A family-based association study of FXYD6 gene polymorphisms and schizophrenia.
- Author:
Li-zi JIAO
1
;
Bing WANG
;
Xiao-rong NIU
;
Xu-dong MA
;
Jian-peng LI
;
Bo SHEN
;
Yan-li HUANG
;
Huan ZHANG
;
Rui ZHANG
;
Jie MA
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Alleles; Female; Genetic Predisposition to Disease; Haplotypes; Humans; Ion Channels; genetics; Linkage Disequilibrium; genetics; Male; Polymorphism, Single Nucleotide; genetics; Schizophrenia; genetics; Young Adult
- From: Chinese Journal of Medical Genetics 2011;28(5):539-542
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the association between the single nucleotide polymorphisms (SNPs) in FXYD6 gene and schizophrenia in a family-trios population.
METHODSSix SNPs (rs10790212, rs11544201, rs555577, rs1815774, rs4938446 and rs497768) in the FXYD6 gene were genotyped by allele-specific PCR method in 101 nuclear families, and transmission disequilibrium test (TDT) was performed.
RESULTSSNPs rs10790212 and rs11544201 showed significant association with schizophrenia (P<0.05). Furthermore, significant association of schizophrenia with the haplotype rs10790212-rs11544201 was found (P<0.05).
CONCLUSIONFXYD6 gene might play an important role in schizophrenia susceptibility and functional analysis of FXYD6 are needed.
