Association of filaggrin gene polymorphism with atopic dermatitis in southern Chinese Han population.
- Author:
Chang-xing LI
1
;
Xue-mei LI
;
Xi-bao ZHANG
;
Chun-lei HAN
;
Ze-lin MA
;
Dong-zi LIN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Asian Continental Ancestry Group; genetics; Base Sequence; Child; Child, Preschool; Dermatitis, Atopic; genetics; Female; Genetic Predisposition to Disease; genetics; Humans; Intermediate Filament Proteins; genetics; Male; Polymorphism, Single Nucleotide; genetics
- From: Chinese Journal of Medical Genetics 2011;28(5):572-574
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of filaggrin gene (FLG) polymorphism with atopic dermatitis (AD) in southern Chinese Han population.
METHODSThe frequencies of the 13 known FLG gene single nucleotide polymorphism(SNPs), including 3321delA, 441delA, 1249insG, E1795X, S3296X, R501X, 2282del4, R2447X, S2889X, 7945delA, 3702delG, Q2417X, R4307X, were detected in a cohort of 50 AD patients and 100 control individuals using polymerase chain reaction (PCR) and DNA sequencing.
RESULTSFLG 3321delA and 441delA were detected in 14 (28%) and 6 (12%) AD patients, respectively. The other 11 SNPs were not detected in the patients. None of the 13 SNPs was detected in the controls.
CONCLUSIONThe results suggested that the FLG gene might be associated with atopic dermatitis susceptibility in southern Chinese Han population.
