Analysis of fetal chromosomal karyotype and etiology in 252 cases of early spontaneous abortion.
- Author:
Hua-kun ZHANG
1
;
Fu-wei LUO
;
Qian GENG
;
Juan LI
;
Qing-zhi LIU
;
Wu-bin CHEN
;
Fang LI
;
Jian-sheng XIE
Author Information
- Publication Type:Journal Article
- MeSH: Abortion, Missed; genetics; Adolescent; Adult; Case-Control Studies; Chorionic Villi; metabolism; Chromosome Aberrations; Female; Humans; Karyotyping; Middle Aged; Pregnancy; Risk Factors; Young Adult
- From: Chinese Journal of Medical Genetics 2011;28(5):575-578
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between fetal chromosomal karyotype and early spontaneous abortion, and the effect of the environmental factors on spontaneous abortion.
METHODSChoronic villi from 252 cases of missed abortion were sampled as patient group and 50 normal pregnancies as control group. Chorionic villi were cultured and karyotype analysis was performed by G-banding. Clinical information was collected.
RESULTSThe rate of chorion chromosome abnormality in the patient group was 58.09%, significantly higher than that in the control group (4.17%) (P<0.01). Among the 140 cases of karyotype abnormalities, 81 were trisomy, 29 were monosomy X and 17 were polyploidy, accounting for 57.86%, 20.71% and 12.14% of total abnormalities, respectively. Long time and low dose radiation exposure of the pregnant female seemed to be related with spontaneous abortion(P<0.01).
CONCLUSIONChorion chromosome abnormality is a major reason of early spontaneous abortion and karyotype analysis of chorionic villus is of clinical importance. For pregnant women, long-term exposure to computers and television seems a risk factor for missed abortion.
