Experimental study on the chemosensitivity of peripheral blood lymphocytes and tumor cells of lung cancer in vitro.

Author: Yanping WANG ¹ ; Xiaohe CHEN ; Qinghua ZHOU ; Yan WANG ; Shulan YUAN ; Yuqiong YANG
Author Information

1. The Key Laboratory of Lung Cancer Molecular Biology of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R.China.
Publication Type:Journal Article
From: Chinese Journal of Lung Cancer 2004;7(6):480-482
CountryChina
Language:Chinese
Abstract:
BACKGROUNDTo study chemosensitivity of anticancer drugs in the peripheral blood lymphocytes(PBL) of lung cancer patients and evaluate the correlation of chemosensitivity of tumor cells and peripheral blood lymphocytes in vitro.
METHODSThe sensitive rate of 15 kinds of anticancer drugs in the peripheral blood lymphocytes and the tumor cells of 74 cases of lung cancer in vitro were tested by the MTT method.
RESULTSThere was no significant difference in the sensitivity of 12 anticancer drugs between PBL and tumor cells of patients with lung cancer (P > 0.05).
CONCLUSIONSThe chemosensitive test of the peripheral blood lymphocytes is valuable for reference of selecting anti-cancer drugs in clinic for lung cancer.