Effect of Runing II on expression of vascular endothelial growth factor in transplanted tumor of mammary cancer MA-891 in TA2 mice.
- Author:
Xue-qing WU
1
;
Shang-pu GAO
;
Ming-chun MU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antineoplastic Agents, Phytogenic; pharmacology; Drugs, Chinese Herbal; pharmacology; Female; Mammary Neoplasms, Experimental; metabolism; Mice; Neoplasm Transplantation; RNA, Messenger; biosynthesis; genetics; Reverse Transcriptase Polymerase Chain Reaction; Vascular Endothelial Growth Factor A; biosynthesis; genetics
- From: Chinese Journal of Integrated Traditional and Western Medicine 2004;24(3):251-253
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of Runing II on expression of vascular endothelial growth factor (VEGF) in transplanted tumor of mammary cancer MA-891 in TA2 mice.
METHODSThe MA-981 mice mammary cancer cell cultivated in vivo was inoculated into the right axilla subcutaneously of TA2 mice to establish the transplanted tumor model, which were treated with Runing II.
RESULTSRuning II could inhibit the growth of transplanted tumor and the occurrence of lung metastasis (P < 0.05), reduce the expression of VEGF protein and mRNA in tumor tissue (P < 0.05).
CONCLUSIONRuning II could reduce the expression of VEGF protein and mRNA, hence to inhibit the growth of tumor and lung metastasis.
