Effect of safflower injection on cardiac energy charge and anti-apoptosis gene bcl-2 in rats' heart.
- Author:
Su-qing ZHANG
1
;
Liang-duo JIANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Apoptosis; drug effects; Carthamus tinctorius; chemistry; Drugs, Chinese Herbal; pharmacology; Energy Metabolism; drug effects; Genes, bcl-2; drug effects; In Vitro Techniques; Injections; Male; Myocardium; metabolism; Proto-Oncogene Proteins c-bcl-2; biosynthesis; genetics; Random Allocation; Rats; Rats, Wistar; Ventricular Function, Left; physiology
- From: Chinese Journal of Integrated Traditional and Western Medicine 2004;24(5):442-444
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of safflower injection (SI) in protecting heart, and on energy charge and anti-apoptosis gen bcl-2 in cardiac tissue.
METHODSRats' Langendorff isolated heart infused model was used in the experiment to study the effect of SI by measuring the cardiac function, energy charge and bcl-2 expression of the cultured heart in the modified Euro-Collins (mEC) heart preserving liquid with or without addition of SI.
RESULTSAs compared with the control, SI showed the effects of improving functions of cardiac contraction and dilation, increasing coronary blood flow, and strengthening the bcl-2 protein expression.
CONCLUSIONSI has excellent effect in protecting heart.
