Effect of heart benefiting recipe in controlling IL-1beta, IL-6 and APPmRNA expression in brain of beta-amyloid protein induced rat model of dementia.
- Author:
Hui ZHOU
1
;
Wei-kang ZHAO
;
Guo-qin JIN
Author Information
- Publication Type:Journal Article
- MeSH: Alzheimer Disease; chemically induced; metabolism; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; biosynthesis; genetics; Animals; Brain; metabolism; Drugs, Chinese Herbal; pharmacology; Interleukin-1; biosynthesis; genetics; Interleukin-6; biosynthesis; genetics; Male; Neuroprotective Agents; pharmacology; RNA, Messenger; biosynthesis; genetics; Random Allocation; Rats
- From: Chinese Journal of Integrated Traditional and Western Medicine 2004;24(6):529-533
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the neuro-immune regulatory mechanism of Heart Benefiting recipe (HBR), an effective recipe for treatment of Alzheimer's disease (AD).
METHODSUsing immunohistochemical and RT-PCR methods, the neuro-immunological pathological changes in the AD rat model induced by beta-amyloid protein (A beta1-40) via lateral cerebral ventricle injection, including mainly the glial fibrillary acidic protein expression and inflammatory cytokines IL-1beta, IL-6mRNA and beta-amyloid protein precursor (APPmRNA) gene expression were studied. And the effects of HBR on these parameters were observed.
RESULTSDeposition of A beta in cerebral tissue could induce activation of stellate glial cells and abnormal increased levels of inflammatory cytokines (IL-1beta and IL-6mRNA), also the elevation of APPmRNA level. HBR could effectively control the above-mentioned pathological changes.
CONCLUSIONHBR could effectively control the inflammation and the A beta immune cascade reaction in brain of AD patients, it is one of the important therapeutic mechanisms of the recipe.
