Experimental study on preventive effect of Radix Paeoniae Rubra to restenosis after carotid balloon injury in high fat-diet rabbits.
- Author:
Hui-min ZHU
1
;
Bi-de ZHU
Author Information
- Publication Type:Journal Article
- MeSH: Angioplasty, Balloon; adverse effects; Animals; Arteriosclerosis; etiology; pathology; therapy; Carotid Artery Injuries; etiology; Carotid Artery, Common; pathology; Carotid Stenosis; etiology; pathology; therapy; Drugs, Chinese Herbal; pharmacology; Hypercholesterolemia; complications; Muscle, Smooth, Vascular; pathology; Paeonia; Proliferating Cell Nuclear Antigen; metabolism; Rabbits; Secondary Prevention
- From: Chinese Journal of Integrated Traditional and Western Medicine 2004;24(6):538-540
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the preventive effect of Radix Paeoniae Rubra (RPR) to restenosis after carotid balloon injury in rabbits.
METHODSThe rabbit model of carotid balloon injury was established adopting Clowes method, and treated with extract of RPR. Component of new genesic intima and expression of proliferating cell nuclear antigen (PCNA) and macrophage was determined by immunochemical stain. The collagen of type I was detected by special staining for blood vessels and the area of new genesic intima was measured by image assay system.
RESULTSRPR could remarkably decreased the PCNA positive expression and inhibit the proliferation of collagen type I and reduce the generating of new intima.
CONCLUSIONRPR has significant preventive effect on the restenosis after carotid ballon injury in high fat-diet induced atherosclerotic rabbits.
