Study on the effect of weitongning on epidermal growth factor and nitric oxide contents in tissue of stomach of rats with gastric ulcer.
- Author:
Xue-gang ZHENG
1
;
Jian-jun ZHANG
;
Yun-chun HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anti-Ulcer Agents; pharmacology; Drugs, Chinese Herbal; pharmacology; Epidermal Growth Factor; metabolism; Female; Gastric Mucosa; metabolism; Male; Nitric Oxide; metabolism; Rats; Rats, Sprague-Dawley; Stomach; metabolism; Stomach Ulcer; metabolism
- From: Chinese Journal of Integrated Traditional and Western Medicine 2004;24(6):549-551
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the therapeutic mechanism of weitongning (WTN) in treating peptic ulcer.
METHODSRat model of chronic gastric ulcer induced by glacial acetic acid was used to observe the effect of WTN on the curative quality, thickness of regenerated mucous membrane, epidermal growth factor (EGF) and nitric oxide (NO) contents in scar tissue around the gastric ulcer.
RESULTSThe thickness of regenerated mucous membrane, EGF and NO contents in peri-ulcer scar tissue were higher in the model rats after WTN treatment than that in the untreated model rats (P<0.01 or P<0.05).
CONCLUSIONWTN could elevate the quality of ulcer curing, to raise the EGF and NO contents in peri-ulcer scar tissue might be one of its mechanisms for preventing relapse of peptic ulcer.
