Preliminary exploration on effect of qilian decoction in intervention treatment of diabetes mellitus type 2 with insulin resistance and its influence on related inflammatory cytokines.
- Author:
Shu-rong GAO
1
;
Jian-hong BU
;
Liang-zheng ZHU
Author Information
- Publication Type:Clinical Trial
- MeSH: Aged; C-Reactive Protein; metabolism; Diabetes Mellitus, Type 2; drug therapy; Drugs, Chinese Herbal; therapeutic use; Female; Humans; Hypoglycemic Agents; therapeutic use; Insulin; blood; therapeutic use; Insulin Resistance; Interleukin-6; blood; Male; Middle Aged; Peptides; blood; Phytotherapy; Tumor Necrosis Factor-alpha; metabolism
- From: Chinese Journal of Integrated Traditional and Western Medicine 2004;24(7):593-595
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the synergistic effect of Qilian decoction (QLD) with corresponding hypoglycemic agents on insulin sensitivity in patients with diabetes mellitus type 2 and its influence on related inflammatory cytokines.
METHODSSixty-two patients with diabetes mellitus type 2 were selected and randomly divided into two groups, they were treated with hypoglycemic agent in routine, and QLD was given orally, one dose taken in twice a day. Parameters as fasting blood glucose, insulin, peptide C, tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), interleukin 6 (IL-6) were measured before and after treatment, and insulin sensitive index (ISI) was also calculated.
RESULTSThe level of fasting blood glucose lowered after treatment in both groups (P<0.01); levels of fasting insulin, peptide C, ISI, TNF-alpha, IL-6 and CRP significantly lowered after treatment (P<0.05 or P<0.01), and the effect was better than that in the control group (P<0.05 or P<0.01).
CONCLUSIONQLD could improve the insulin resistance and lower the levels of related inflammatory cytokines.
