Effect of niupo zhibao pellet on transforming growth factor-beta1 and its receptor's expression in endotoxic shock rats with lung injury.
- Author:
Shao-hui DU
1
;
Zhi-wei XU
;
Dong-feng CHEN
;
Hui LI
;
Yiwei LI
;
Xin LIAO
;
Zhijun WEI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Drugs, Chinese Herbal; pharmacology; Female; Galactosamine; Lipopolysaccharides; Male; Rats; Rats, Sprague-Dawley; Receptors, Transforming Growth Factor beta; biosynthesis; Respiratory Distress Syndrome, Adult; etiology; metabolism; Shock, Septic; chemically induced; complications; metabolism; Transforming Growth Factor beta; biosynthesis; Transforming Growth Factor beta1
- From: Chinese Journal of Integrated Traditional and Western Medicine 2004;24(7):613-616
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the influence of Niupo Zhibao pellet (NZP) on transforming growth factor-beta1 (TGF-beta1) and its receptor's expression.
METHODSEndotoxic shock model was established by intravenous injection of lipopolysaccharide (LPS) 1.5 mg/kg and intraperitoneal injection of D-galactosamine 100 mg/kg, and intervened by NZP, TGF-beta1 and its receptor's expression in lung tissue were detected by immunohistochemical method.
RESULTSNZP could enhance the TGF-beta1 and its receptor's expression in endotoxic shock lung tissue, and reduce the injury of lung.
CONCLUSIONThe mechanism of NZP in reducing endotoxic shock lung injury is possibly related with its effect in enhancing the TGF-beta1 and its receptor's expression in lung tissue.
