Bioactive Constituents from the Leaves of Zanthoxylum schinifolium.
- Author:
Su Yang JEONG
1
;
Phi Hung NGUYEN
;
Bing Tian ZHAO
;
Byung Sun MIN
;
Eun Sook MA
;
Mi Hee WOO
Author Information
1. College of Pharmacy, Catholic University of Daegu, Gyeongsan 712-702, Korea. woomh@cu.ac.kr
- Publication Type:Original Article
- Keywords:
Zanthoxylum schinifolium;
Rutaceae;
Cytotoxicity;
Collinin;
Phytol
- MeSH:
Inhibitory Concentration 50;
Palmitic Acid;
Phytol;
Rutaceae;
Statistics as Topic;
T-Lymphocytes;
Zanthoxylum*
- From:Natural Product Sciences
2015;21(1):1-5
- CountryRepublic of Korea
- Language:English
-
Abstract:
Activity-guided separation of the methylene chloride-soluble fraction of the leaves of Zanthoxylum schinifolium, resulted in the isolation of four coumarinoids (1 - 4), two triterpenoids (5, 6) and three fatty acid derivatives (7 - 9) as active principles. Their chemical structures were identified as collinin (1), 8-methoxyanisocoumarin (2), 7-(6'R-hydroxy-3',7'-dimethylocta-2',7'-dienyloxy)-coumarin (3), (E)-4-methly-6-(coumarin-7'-yloxy) hex-4-enal (4), lupeol (5), epi-lupeol (6), phytol (7), hexadec-3-enoic acid (8) and palmitic acid (9), on the basis of spectroscopic (1D, 2D and MS) data analyses and comparing with the data published in the literatures. Compounds 1 and 7 showed potent cytotoxicity against Jurkat T cells with IC50 values of 45.58 and 47.51 microM, respectively. The others showed moderate activity with IC50 values ranging around 80.58 to 85.83 microM, while the positive control, auraptene, possessed an IC50 value of 55.36 microM.
