Analysis of the toll-like receptor 2 Arg753Gln gene polymorphisms of acne patients of Gan-depression induced qi stagnation syndrome and damp-heat in the interior syndrome.
- Author:
Li-Ming TIAN
1
;
Wei-Zhen WANG
;
Tin YANG
Author Information
- Publication Type:Journal Article
- MeSH: Acne Vulgaris; diagnosis; ethnology; genetics; Adolescent; Adult; Asian Continental Ancestry Group; genetics; Case-Control Studies; Female; Gene Frequency; Genotype; Humans; Male; Medicine, Chinese Traditional; Phenotype; Polymorphism, Genetic; Qi; Toll-Like Receptor 2; genetics; Young Adult
- From: Chinese Journal of Integrated Traditional and Western Medicine 2012;32(1):50-53
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the toll-like receptor 2 (TLR2) Arg753Gln gene polymorphisms of acne patients of Gan-depression induced qi stagnation syndrome and damp-heat in the interior syndrome, thus laying the foundation for genetics studies on its occurrence.
METHODSThe distribution and the frequency of allelic genes were studied in 75 acne patients of damp-heat in the interior syndrome, and 87 acne patients with Gan-depression induced qi stagnation syndrome, as well as 70 healthy subjects (as the normal control group) using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.
RESULTSThere was significant difference in the frequency of the genotype Arg/Gln + Gln/Gln in the TLR2 Arg753Gln genetic polymorphisms [26. 44% (23/87) in Gan-depression induced qi stagnation syndrome, 41.33% (31/75) in damp-heat in the interior syndrome, and 12.86% (9/70) in the normal control group] (P < 0.05).
CONCLUSIONThe existence of 753Gln allele in the Arg753Gln of TLR2 increased the onset risk of acne patients of Gan-depression induced qi stagnation syndrome and damp-heat in the interior syndrome.
