Isolation and Structure Determination of an Imidazo-pyrimidine, 5-Chlorocavernicolin, Maleimide oximes and Nucleosides from a Marine Sponge Extract.
- Author:
Roshan R KULKARNI
1
;
Jang Hoon KIM
;
Young Ho KIM
;
Sangtaek OH
;
Minkyun NA
Author Information
1. College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea. mkna@cnu.ac.kr
- Publication Type:Original Article
- Keywords:
Imidazo-pyrimidine;
5-Chlorocavernicolin;
Maleimide-5-oxime;
Nucleoside;
Soluble epoxide hydrolase;
Wnt/beta-catenine signaling
- MeSH:
Adenine;
Adenosine;
Nucleosides*;
Oximes*;
Porifera*;
Thymidine;
Uridine
- From:Natural Product Sciences
2015;21(1):25-29
- CountryRepublic of Korea
- Language:English
-
Abstract:
In a continuation of our studies to discover bioactive secondary metabolites from marine sources, we further investigated samples from a tryptamine and phenyl-alkane producing sponge, which resulted in the isolation of four uncommon small molecules and five nucleosides. Their structures were determined to be 7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one (1), 5-chlorocavernicolin (2), maleimide-5-oxime (3), 3-methylmaleimide-5-oxime (4), uridine (5), 2'-deoxyuridine (6), thymidine (7), adenine (8), and adenosine (9) by spectroscopic analyses. The isolated compounds were evaluated for inhibitory activity against soluble epoxide hydrolase (sEH) as well as the Wnt/beta-catenine signaling pathway.
