Association between tumor necrosis factor alpha gene polymorphism and colorectal cancer.
- Author:
Guo-yang WU
1
;
Xiao-min WANG
;
Michael KEESE
;
Till HASENBERG
;
Jörg W STURM
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Alleles; Case-Control Studies; Colorectal Neoplasms; genetics; pathology; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Neoplasm Staging; Polymorphism, Single Nucleotide; Tumor Necrosis Factor-alpha; genetics
- From: Chinese Journal of Gastrointestinal Surgery 2008;11(6):569-571
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo elucidate the association of TNF-alpha-308G/A gene functional polymorphism with the development and progression of colorectal cancer.
METHODSPCR-RFLP was employed to detect the TNF-alpha-308 G/A genotypes in 157 colorectal cancer patients and 117 healthy controls.
RESULTSThe frequency of TNF-alpha-308 genotype and allele were not significantly different between colorectal cancer patients and healthy controls (genotype chi(2)=1.054, P=0.591, allele chi(2)=0.404, P=0.525). The frequency of A/A genotype and A allele in III+IV stage (62 patients in total) were higher than those in I+II stages (85 patients in total) (A allele: 22.6% vs 12.9%, A/A genotype: 8.1% vs 1.2%), and the differences were significant (genotype P=0.048, OR=7.368, 95% CI=0.839-64.743, allele chi(2)=4.720, P=0.03, OR=1.962, 95% CI=1.061-3.628). The frequency of TNF-alpha-308 genotype were not significantly different among different colorectal cancer grades (chi(2)=3.009,P=0.591).
CONCLUSIONTNF-alpha-308G/A gene polymorphism is not associated with the development of colorectal cancer, but TNF-alpha-308 A/A genotype and A allele are related to the progression of colorectal cancer.
