Association between expressions of HSP70, HSP90 and efficacy of chemotherapy in colorectal cancer patients with unresectable liver metastasis.
- Author:
Chao-wu CHEN
1
;
Zhong-cheng HUANG
;
Yun LIU
;
Zhi-jun YUAN
;
Guo-qing NING
;
Li-xin TAN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; therapeutic use; Colorectal Neoplasms; drug therapy; metabolism; pathology; Female; HSP70 Heat-Shock Proteins; metabolism; HSP90 Heat-Shock Proteins; metabolism; Humans; Liver Neoplasms; drug therapy; metabolism; secondary; Male; Middle Aged; Prognosis; Treatment Outcome
- From: Chinese Journal of Gastrointestinal Surgery 2009;12(4):346-349
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between expressions of HSP70, HSP90 and efficacy of chemotherapy in colorectal cancer patients with unresectable liver metastasis.
METHODSData of 52 colorectal cancer cases, whose primary colorectal focuses were resected but hepatic metastatic tumors were unresectable, were reviewed retrospectively. All the patients underwent FOLFOX4 regimen well. Immunohistochemistry assay was applied to determine the expressions of HSP70 and HSP90 in primary focus tissues. The number and size of hepatic metastatic tumors pre- and post-chemotherapy were compared by CT scanning.
RESULTSPartial remission(PR) rate was 33.3% in cases with up-regulated expression of HSP70, while 64.5% in cases with down-regulated expression of HSP70, whose difference was significant. PR rate was 50% in cases with up-regulated expression of HSP90, and 53.1% in the others with down-regulated expression of HSP90, whose difference was not significant.
CONCLUSIONSFOLFOX4 regimen has advantages in cases with lower HSP70 expression over those with higher HSP70 expression. HSP90 expression level is not associated with the efficacy of FOLFOX4 regimen.
