Relationship between the protein expression of P53, c-erbB-2, vascular endothelial growth factor and CD44 and the survival rates of stage II( colorectal cancer patients without radiochemotherapy after radical resection.
- Author:
Jie-er YING
1
;
Li-song TENG
;
Gu ZHANG
;
Wang-xia LV
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; metabolism; mortality; pathology; Female; Follow-Up Studies; Humans; Hyaluronan Receptors; metabolism; Male; Middle Aged; Neoplasm Staging; Proto-Oncogene Proteins c-bcl-2; metabolism; Survival Rate; Tumor Suppressor Protein p53; metabolism; Vascular Endothelial Growth Factor A; metabolism
- From: Chinese Journal of Gastrointestinal Surgery 2009;12(4):395-398
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relation between protein expression of 4 genes [P53,c-erbB-2,vascular endothelial factors(VEGF) and CD44]and survival rate in stage II( colorectal cancer(CRC) patients without radiochemotherapy after radical resection.
METHODSOne hundred and fifty-nine cases of stage II(CRC without radiochemotherapy were enrolled in this study. The clinicopathological date and 5-year follow-up data were reviewed. Streptavidin-peroxidase immunohistochemical technique was used to detect the expression of P53, c-erbB-2, VEGF and CD44 in formalin-fixed, paraffin embedded sections of CRC tissues from above 159 patients.
RESULTSThe 5-year survival rate was 82.4%. The rates of positive expression of P53, c-erbB-2, VEGF and CD44 were 58.5%(93/159), 26.4%(42/159), 57.9%(92/159) and 40.0%(54/159) respectively. The 5-year survival rates of positive expression patients were not significantly different with those of negative expression. chi(2) analysis showed that the positive expressions of 4 genes had no relationships with the prognosis.
CONCLUSIONThe expression of 4 gene proteins has no relationship with the prognosis of stage II( CRC patients without radiochemotherapy after radical resection.
