Comparative study on the efficacy of intracoronary infusion with various types of autologous bone marrow stem cells for patients with dilated cardiomyopathy
10.3760/cma.j.issn.0253-3758.2012.07.007
- VernacularTitle:不同类型骨髓干细胞移植治疗扩张型心肌病的疗效对比
- Author:
Wen-Tao XIAO
1
;
Li-Jun GAO
;
Chuan-Yu GAO
;
Yong-Ju GAO
;
Guo-You DAI
;
Mu-Wei LI
;
Xian-Pei WANG
Author Information
1. 郑州大学人民医院
- Keywords:
Cardiomyopathy,dilated;
Myeloid progenitor cells;
Stem cell transplantation
- From:
Chinese Journal of Cardiology
2012;40(7):575-578
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effects of intracoronary infusion of mononuclear stem cells (MNCs) or mesenchymal stem cells (MSCs) in patients with dilated cardiomyopathy (DCM).Methods DCM patients with left ventricular ejection fraction ( LVEF ) ＜ 40％ were randomized to intracoronary infusion of MNCs [ (5.1 ± 2.0) × 108,n =16] or MSCs [ (4.9 ± 1.7 ) × 108,n =17 ] or equal volume normal saline ( n =20 ) through the guiding catheter. Changes of left ventricular end-diastolic diameter (LVEDd),LVEF and myocardium perfusion defects were assessed before and at (30 ±3) days and (90 ± 7) days after the procedure.Malignant cardiovascular events were also recorded.Results ( 1 ) One month after the procedure,LVEF in transplantation groups significantly increased compared to before procedure ( all P ＜0.05),and significant increase of LVEF was observed only in MSCs transplantation group compared to control group ( P ＜ 0.05 ).However,absolute changes of LVEDd and perfusion defects of myocardium were similar among and within groups (P ＞ 0.05 ).(2)Gomparing with before procedure and control group,LVEF in transplantation groups increased significantly in three months after the procedure (P ＜ 0.05 ),but there were no significant differences between transplantation groups ( P ＞ 0.05 ).LVEDd and myocardium perfusion defects in transplantation groups improved significantly compared with that of before procedure (P ＜0.05 ),while significant decrease of myocardium perfusion defects was only observed in patients treated with MSCs compared with control group at three months after procedure ( P ＜ 0.05 ). ( 3 ) There were no significant differences in major cardiovascular events between transplantation group and control during followup ( P ＞ 0.05).Conclusions Intracoronary bone marrow stem cells transplantation is safe and effective for DCM patients while the efficacy of MSCs and MNCs transplantation is comparable.
