Association between paraoxonase concentration and risk of acute coronary syndrome
10.3760/cma.j.issn.0253-3758.2012.07.008
- VernacularTitle:血清对氧磷酶浓度与急性冠状动脉综合征的关系
- Author:
Qun LU
1
;
Gang TIAN
;
Yong ZHANG
;
Min LU
;
Ai-Qun MA
Author Information
1. 西安交通大学医学院附属第一医院
- Keywords:
Coronary artery disease;
Paraoxon;
Case control study;
Atherosclerosis
- From:
Chinese Journal of Cardiology
2012;40(7):579-582
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between paraoxonase (PON) concentration and the risk of acute coronary syndrome (ACS).Methods The levels of serum PON were detected by enzyme-linked immunosorbent assay in 229 patients with confirmed ACS and 129 control subjects without CHD.Logistic regression analysis and receiver operating characteristic (ROC) curve analysis were applied to analyze the association between PON and ACS.Results PON was significantly lower in ACS group than in control group [ lgPON:( 5.72 ± 0.73 ) ng/L vs.( 5.07 ± 0.57 ) ng/L,P ＜ 0.05].Logistic regression analysis showed that the level of PON was an independent risk factor of ACS (regression coeffient was - 1.793 in univariate logistic regression,OR =0.166,95％ CI:0.088 - 0.316; - 0.779 in multivariate logistic regression,OR =0.459,95％ CI:0.222 -0.949).ROC analysis showed that the optimal diagnostic cut-off point of PON for ACS was 180 mg/L ( sensitivity:83.3％,specificity:71.2％ ).Multiple stepwise regression analysis revealed that there was no significant correlation between lgPON and Gensini score in ACS patients.Conclusion Lower PON is linked with increased risk of ACS,but does not relate with the severity of coronary stenosis.
