Association between fractional flow reserve and quantitative coronary angiography parameters in intermediate coronary artery stenosis
10.3760/cma.j.issn.0253-3758.2012.09.005
- VernacularTitle:冠状动脉临界病变定量冠状动脉造影参数与心肌流量储备分数的关系
- Author:
Li-Jie SUN
1
;
Lin MI
;
Ming CUI
;
Li-Jun GUO
;
Yong-Zhen ZHANG
;
Fu-Chun ZHANG
;
Jie NIU
;
Hai-Yan LI
;
Gui-Song WANG
;
Jiang-Li HAN
;
Wei GAO
;
Dan LI
;
Cui-Ping LI
Author Information
1. 北京大学第三医院
- Keywords:
Coronary disease;
Fractional flow reserve,myocardial;
Coronary angiography
- From:
Chinese Journal of Cardiology
2012;40(9):742-746
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between quantitative coronary angiography (QCA) parameters and fractional flow reserve (FFR) for identifying ideal angiographic parameters predictive of myocardial ischemia.Methods The study included 121 lesions with QCA and FFR data from 106 patients [ mean age:(63 ± 10 ) years ].The lesions were grouped into FFR ＞ 0.75 group and FFR ≤0.75 group.Assessed parameters by QCA included percentage diameter stenosis,minimum luminal diameter ( MLD),percentage area stenosis,minimum luminal area (MLA),reference vessel diameter (RVD) and lesion length (LL).Correlation analysis was used to identify the relationship between QCA parameters and FFR value,and receiver operating characteristic (ROC) curve was used to determine parameters predictive of FFR≤0.75.Results LL was significantly higher[ ( 14.8 ±7.9)mm vs.( 10.7 ±5.4) mm,P=0.024]whileMLD [(1.47 ±0.31)mm vs.(1.82 ± 0.51) mm,P=0.028],RVD [(2.30 ±0.50) mm vs.(2.81 ±0.64) mm,P=0.036],andMLA [(2.30±1.50)mm2 vs.(3.60 ±2.30) mm2,P=0.038]were significantly lower in FFR≤0.75 group than in FFR ＞0.75 group.LL (r =-0.209,P =0.040) was negatively correlated with FFR,and MLD ( r=0.414,P=0.040),RVD ( r =0.303,P =0.000) and MLA (r =0.315,P =0.002) were positively correlated with FFR.ROC analysis showed that MLD ≥ 1.6 mm was the best cut-off value to predict FFR ＞ 0.75 with sensitivity 63％,specificity 82％,and positive predictive value 96％.Conclusions QCA derived anatomic parameters of intermediate coronary lesions correlate to FFR value in some extent.MLD ≥ 1.6 mm is the best cut-off value to predict FFR ＞ 0.75 in patients with intermediate coronary lesions.
