Distributional characteristics of acylation stimulating protein gene 301T > C polymorphism and association with serum triglyceride in Han and Uighur residents in Xinjiang.
- Author:
Si-jin YANG
1
;
Yi-tong MA
;
Xiang XIE
;
Yi-ning YANG
;
Xiang MA
;
Xiao-mei LI
;
Fen LIU
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; Complement C3; Ethnic Groups; genetics; Female; Gene Frequency; Genotype; Humans; Intercellular Signaling Peptides and Proteins; genetics; Male; Middle Aged; Polymorphism, Single Nucleotide; Triglycerides; blood
- From: Chinese Journal of Cardiology 2012;40(11):929-932
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the distributional characteristics of acylation stimulating protein (ASP) gene polymorphism and the association with serum lipid level of Chinese Han and Uighur residents in Xinjiang.
METHODGenotypes of the ASP gene 301T > C polymorphism was detected by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) in 527 Uighur and 407 Han residents.
RESULTSThe frequencies of TT, TC and CC genotype of ASP gene 301T > C were 74.9%, 21.3% and 3.6% in Han group and 47.6, 40.2% and 12.1% in Uighur group (P < 0.05). Serum triglyceride level was significantly higher in C allele carrier (TC + CC genotype) than in TT genotype carrier of both Han and Uighur individuals. After adjusting for age, gender, smoking, drinking, BMI and serum total cholesterol, logistic regression analyses revealed that individuals carrying C allele (TC + CC genotype) faced an increased risk of increased serum triglyceride level than individuals carrying TT genotype in both Han and Uighur individuals (OR = 3.31, 95%CI: 1.31 - 8.36 in Uighur group; OR = 3.98, 95%CI: 1.81 - 8.74 in Han group).
CONCLUSIONThere is a significant difference on mutational frequencies of the ASP gene 301T > C polymorphism between Uighur and Han residents in Xinjiang and C allele carriers face an increased risk for hypertriglyceridemia in both Uighur and Han residents in Xinjiang.
