Association of XPC and XPG polymorphisms with the risk of hepatocellular carcinoma.
- Author:
Long-man LI
1
;
Xiao-yun ZENG
;
Long JI
;
Xue-jiao FAN
;
Yong-qiang LI
;
Xiao-hua HU
;
Xiao-qiang QIU
;
Hong-ping YU
Author Information
- Publication Type:Journal Article
- MeSH: Carcinoma, Hepatocellular; genetics; Case-Control Studies; DNA Repair; DNA-Binding Proteins; genetics; Endonucleases; genetics; Female; Genetic Predisposition to Disease; Genotype; Humans; Liver Neoplasms; genetics; Male; Middle Aged; Nuclear Proteins; genetics; Polymorphism, Single Nucleotide; Transcription Factors; genetics
- From: Chinese Journal of Hepatology 2010;18(4):271-275
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate whether the polymorphism of DNA repair genes XPC (Ala499Val and Lys939Gln) and XPG (His1104Asp) is associated with the susceptibility to hepatocellular carcinoma (HCC).
METHODSA hospital-based case-control study was conducted in 500 cases with HCC and 507 controls. Genotypes of XPC and XPG were determined by real-time polymerase chain reaction with the TaqMan MGB probe.
RESULTSCompared to the CC genotype, the CT genotype and the TT genotype of XPC Ala499Val were not associated with the susceptibility to HCC (adjusted OR = 1.34, 95% CI: 0.85-2.12; adjusted OR = 1.30, 95% CI: 0.68-2.51, respectively). Compared to the AA genotype, the AC genotype and the CC genotype of Lys939Gln were not associated with the susceptibility to HCC (adjusted OR = 1.20, 95% CI: 0.78-1.85; adjusted OR = 1.81, 95% CI: 0.88-3.73, respectively). Compared to the CC genotype, the CG genotype and the GG genotype of XPG His1104Asp were not associated with the susceptibility to HCC (adjusted OR = 0.85, 95% CI: 0.56-1.27; adjusted OR = 1.12, 95% CI: 0.67-1.87, respectively) However, the stratified analysis revealed that the females with the AC+CC genotype of XPC Lys939Gln had increased risk of HCC compared to those with AA genotype (OR = 2.17, 95% CI: 1.01-4.64).
CONCLUSIONOur results suggest that XPC and XPG polymorphisms do not independently affect on the susceptibility to HCC, but the joint effect of C allele of XPC Lys939Gln and female may modify the risk of HCC.
