The expression of integrin beta 1 in normal hepatic tissues, hepatic cirrhosis tissues and hepatocellular carcinoma.
- VernacularTitle:肝硬化及肝癌组织中整合素β1表达的差异
- Author:
Gang ZHAO
1
;
Jing CUI
;
Qi QIN
;
Shao-shan LI
;
Tao YIN
;
Li-bo CHEN
;
He-shui WU
;
Chun-you WANG
Author Information
- Publication Type:Journal Article
- MeSH: Carcinoma, Hepatocellular; metabolism; pathology; Humans; Integrin beta1; genetics; metabolism; Liver; metabolism; Liver Cirrhosis; metabolism; pathology; Liver Neoplasms; metabolism; pathology; RNA, Messenger; genetics
- From: Chinese Journal of Hepatology 2010;18(5):353-356
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of integrin beta 1 in hepatic cirrhosis (HC) and hepatocellular carcinoma (HCC).
METHODSThe expression of integrin beta 1 in HCC, HC and normal liver tissues was detected by reverse transcriptase-polymerase chain reaction (RT-PCR) and laser scanning confocal microscopy (LSCM). The association between the integrin beta 1 expression and clinical pathological features were analyzed.
RESULTS(1) The levels of integrin beta 1 mRNA and protein in the HCC (1.30+/-0.24, 90.50+/-33.50) and HC (1.58+/-0.31, 123.10+/-38.90) were much higher than that in the normal hepatic tissue (0.37+/-0.08, 11.90+/-6.00) (P less than 0.05). (2) The expression of integrin beta 1 was associated with HC (r = 0.692), Edmondson pathologic grade (F = 13.618), encapsulation (F = 17.857) and metastasis (F = 38.857) (P less than 0.01).
CONCLUSIONSIntegrin beta 1 may play an important role in the development of hepatic fibrosis, hepatic cirrhosis and hepatocellular carcinoma.
