The relationship between FHIT and WWOX expression and clinicopathological features in hepatocellular carcinoma.
- Author:
Jie LIN
1
;
Bin WANG
;
Ai-min HUANG
;
Xiao-jun WANG
Author Information
- Publication Type:Journal Article
- MeSH: Acid Anhydride Hydrolases; genetics; Adolescent; Adult; Aged; Carcinoma, Hepatocellular; genetics; pathology; Female; Gene Expression Profiling; Humans; Liver Neoplasms; genetics; pathology; Male; Middle Aged; Neoplasm Proteins; genetics; Oxidoreductases; genetics; Prognosis; Tumor Suppressor Proteins; genetics; WW Domain-Containing Oxidoreductase; Young Adult
- From: Chinese Journal of Hepatology 2010;18(5):357-360
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the relationship between FHIT and WWOX expression and clinicopathological features in hepatocellular carcinoma (HCC).
METHODThe expression of FHIT and WWOX were determined by immunohistochemistry in 142 patients with HCC.
RESULTSAbsent or reduced FHIT and WWOX expression was observed in 68.3% and 77.5% of HCCs, respectively. The expression of FHIT was significantly correlated with that of WWOX (P < 0.01), and progressive loss of FHIT and WWOX expression were observed as tumor differentiation decreased and tumor grade increased (P < 0.05). Absent/reduced FHIT and WWOX expression was associated with tumor invasion and metastasis (P < 0.05). In addition, the expression of FHIT and WWOX in HCC with recrudesce were lower than that in those without recrudesce (P < 0.05).
CONCLUSIONSAbsent/reduced FHIT and WWOX expression is associated with poor prognosis.
