Comparative genomic hybridization analysis of nonsyndromic cleft lip with palate.
- Author:
Wen-Guang ZHANG
1
;
Shao-Jun LUO
;
Shao-Fang ZHU
;
Shao-Ming TANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Child; Child, Preschool; China; ethnology; Cleft Lip; genetics; Cleft Palate; genetics; Comparative Genomic Hybridization; DNA; Genetic Variation; Genotype; Humans; Infant; Mutation; Phenotype; Young Adult
- From: Chinese Journal of Plastic Surgery 2008;24(2):123-125
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo identify the genetic alterations in nonsyndromic cleft lip and palate (NSCLP).
METHODSComparative genomic hybridization was applied to investigate the genomic imbalance (the gain or loss of genetic material) in 7 cases of NSCLP.
RESULTSIt showed that the loss of chromosome DNA copies happened in chromosome 6, 7, 10, 13, 14, 16, 20, 22 and the gain of chromosome DNA copies happened in chromosome 5, 15, 18, 19. Conclusions 13q had a high frequency (71.4%) of chromosome loss.
CONCLUSIONSAbnormal chromosome DNA copies happen in all the patients with NSCLP. Most of the patients have chromosome DNA copies loss. It suggests that loss of inhibitory gene may be related to the NSCLP. The related inhibitory gene may locate in 13q.
