Expression and clinical significance of cyclin H and CDK7 in human hemangiomas.
- Author:
Juan LIU
1
;
Duan-Lian ZHANG
;
Sheng-Guo SHAN
Author Information
- Publication Type:Journal Article
- MeSH: Cyclin H; metabolism; Cyclin-Dependent Kinases; metabolism; Hemangioma; metabolism; Humans; Immunohistochemistry; Skin Neoplasms; metabolism
- From: Chinese Journal of Plastic Surgery 2008;24(4):300-302
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression and clinical significance of cyclin H and cyclin-dependent kinase 7 (CDK7) in human hemangiomas.
METHODSImmunohistochemistry technique was used to measure the expression of cyclin H and CDK7 proteins in proliferative, involuting hemangiomas and normal skin tissues. Immunohistochemical technique for factor VIII-related antigen was used to prove that the cells which expressed cyclin H and CDK7 were endothelial cells. Average optical density and positive area of the expression of cyclin H and CDK7 proteins in proliferative, involuting hemangiomas and normal skin tissues were measured by image analysis (HPIAS-1000).
RESULTSThe expression of cyclin H and CDK7 protein in proliferating hemangiomas was significantly higher than that in involuting hemangiomas and normal skin tissues (P < 0.01). But no significant difference was found in the expression of cyclin H and CDK7 protein between involuting hemangiomas and normal skin tissues (P > 0.05).
CONCLUSIONScyclin H and CDK7 may play an important role in the generation and development of human hemangiomas.
