Relationship of nonsyndromic cleft lip and/or palate and poliovirus receptor-related 1 exon 3 polymorphisms in Han people of Jiangzhe area.

Author: Xiong ZHAO ¹ ; Run-song JIANG ; Rui LIU ; Wen-song YE ; Ning WANG ; Shi-qiang SHANG ; Ye-feng DAI ; Xu-fei ZHAO
Author Information

1. Department of Burns, the Children' s Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Publication Type:Journal Article
MeSH: Asian Continental Ancestry Group; genetics; Cell Adhesion Molecules; genetics; Child, Preschool; Cleft Lip; genetics; Cleft Palate; genetics; Exons; Female; Gene Frequency; Genotype; Humans; Infant; Male; Nectins; Pedigree; Polymorphism, Genetic; Receptors, Virus; genetics
From: Chinese Journal of Plastic Surgery 2009;25(1):31-33
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo study the relationship of nonsyndromic cleft lip and/or palate (NSCL/P) and poliovirus receptor-related 1 exon3 (PVRL1exon3) polymorphisms in Han People of Jiangzhe area.
METHODSPVRL1exon3 was examined by polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) technique in the 50 patients with NSCL/P and 85 healthy parents.
RESULTSNo W185X mutation was found in the PVRL1exon 3.
CONCLUSIONIt indicates that there is no relationship between NSCL/P and PVRL1exon3 in Han People in Jiangzhe area.