The immunological effects of three doses of a live attenuated hepatitis A vaccine (H2 strain) in 8 years
10.3760/cma.j.issn.1003-9279.2009.03.007
- VernacularTitle:接种3剂甲肝减毒活疫苗8年的免疫学效果
- Author:
Huai-Feng LIU
1
;
Xin-Jiang ZHANG
;
Jian-Li ZHANG
;
Zhi-Yong HAO
;
Zhi-Yong ZHANG
;
Jing-Chen MA
;
Ji-Chao CHEN
;
Juan CHU
;
Xuan-Yi WANG
;
Zhi-Yi XU
Author Information
1. 河北省正定县中医院
- Keywords:
Hepatitis A virus;
Vaccines,attenuated;
Immunization secondary;
Immunoconpetence
- From:
Chinese Journal of Experimental and Clinical Virology
2009;23(3):180-181
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the immunohigical effects of three doses of H2 strain live attenuated hepatitis A vaccine 8 years after the administration and to compare with that of one dose of the vaccine. Methods In a country area, 110 children of 1 to 7 years old susceptible to HAV were screened and administered with one dose of the vaccine, as group B ; Group A were 42 children from one of the villages and administered with 3 doses of the vaccine according to 0, 2, 6 month schedule. Blood samples were taken for the children 1, 2, 6, 7, 8,12, 24, 36 and 96 months after the administrations respectively and detected for anti-HAV antibody. Results For group B, the sero conversion rate of anti-HAV and GMC reached peak at 92.2% and 126.2 mIU/ml respectively,and then, began to drop with time; For group A, after 2 dose of the vaccine, the sero-conversion rate reached 100%, and the GMC reached peak of 2 739 mIU/ml one month after the third dose at 7 months. So that, group A has a better short-term immunological effects than that of group B. During 36 through 96 months, the anti-HAV positive rate in group B was 75%-71% and 80-89 mIU/ml respectively, and comparatively in group A were 100% and 918.2-480.6 mIU/ml respectively. The differences between group A and B were significantly important. Conclusion A 3-dose schedule administration of H2 strain live attenuated hepatitis .A vaccine has better immunological effects than 1-dose schedule in 8years and further observations are needed.
