Study on the relationship of serum vitamin E and liver pathological features in the patients with chronic hepatitis B
10.3760/cma.j.issn.1003-9279.2009.03.016
- VernacularTitle:慢性乙型肝炎患者血清维生素E水平与肝组织病理的关系研究
- Author:
Xiao-Peng FAN
1
;
Kai WANG
;
Guo-Wei WANG
;
Yu-Chen FAN
Author Information
1. 山东大学齐鲁医院
- Keywords:
Vitamin E;
Hepatitis B,chronic;
Oxidative stress;
Histopathology
- From:
Chinese Journal of Experimental and Clinical Virology
2009;23(3):208-210
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study on the relationship of serum vitamin E and liver pathological features in the patients with chronic hepatitis B. Methods Sixty-six patients with chronic hepatitis B and ten healthy controls were enrolled in this present study. The serum vitamin E level was measured spectrophotometrically. Comparisons of liver function test, HBeAg and HBV DNA level were conducted among different liver pathological features including inflammatory grading and fibrosis staging. Results Compared with healthy controls, the serum level of vitamin E was significantly decreased in the patients with chronic hepatitis B, especially in those with elevated ALT activity. In comparison between HBeAg positive group and HBeAg negative group, the serum level of vitamin E of the former group did not significantly changed (P 0.05). Furthermore, the serum level of vitamin E has been demonstrated to be negatively associated with the inflammation grading in the patients with chronic hepatitis B. However, there was no significant association between the serum vitamin E and liver fibrosis staging. Conclusion Vitamin E, as one of the important anti-oxidants, was demonstrated to be implicated in the progression of liver inflammation in the patients with chronic hepatitis B. Furthermore, the supplement of vitamin E would be a potential therapy for attenuate the inflammatory response.
