Comparison of clinical features from patients with chronic hepatitis B between HBeAg negative and positive

VernacularTitle:HBeAg阴性与阳性慢性乙肝患者的临床对比分析
Author: Qi-Huan XU ¹ ; Xin SHU ; Lu-Biao CHEN ; Ka ZHANG ; Gang LI
Author Information

1. 中山大学附属第三医院
Keywords: Hepatitis B virus; Hepatitis B e antigens; DNA; Diagnosis; Disease attributes
From: Chinese Journal of Experimental and Clinical Virology 2009;23(3):211-213
CountryChina
Language:Chinese
Abstract: Objective To analyze different clinical features from patients with chronic hepatitis B between HBeAg negative and positive. Methods 354 patients with chronic hepatitis B (124 cases with HBeAg positive and 230 cases with HBeAg negative) were enrolled into this retrospective investigation. Comparisons were conducted according to their demographic, liver biochemical, virological characters and clinical diagnosis types.chronic hepatitis occupied a lower proportion (P=0.007and 0.014). But fulminant hepatitis had a higher HBeAg positive group,but TBil in HBeAg negative group was higher; AST had no statistical significance between than HBeAg positive group(37.4% vs 55.6%, P=0.1301). Conclusion HBeAg-negative patients compared with HBeAg-positive patients had older age, lower serum HBV DNA level and other characteristics; HBeAg-negative patients maybe had serious disease.