Pregnant women hepatitis B markers investigation and analysis of intrauterine infection.
- Author:
Hui-Fen LU
1
;
Wen-Jun JIN
;
Xioa-Hong HUANG
;
Qin-Ying ZHAO
;
Hua-Ying MAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Female; Hepatitis B; blood; immunology; virology; Hepatitis B Antibodies; blood; immunology; Hepatitis B Antigens; blood; immunology; Hepatitis B virus; genetics; immunology; isolation & purification; Humans; Pregnancy; Pregnancy Complications, Infectious; blood; immunology; virology; Uterine Diseases; blood; immunology; virology; Young Adult
- From: Chinese Journal of Experimental and Clinical Virology 2009;23(3):235-237
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between the hepatitis B virus (HBV) infection in pregnant women and intrauterine infection in local region.
METHODSThe markers of hepatitis B (HBVM) were determined by time-resolved fluoroimmunoassay and HBV-DNA were determined by FQ-PCR.
RESULTSA total of 1262 pregnant women were examined the HBVM, 2.6%, 38.2%, 0.9%, 22.6%, 23.1% subjects were identified HBsAg, HBsAb, HBeAg, HBeAb, HBcAb positive respectively. In 33 cases of serum HBsAg-positive pregnant women, HBV-DNA were observed in most of 11 cases of pregnant women with HBeAg-positive and intrauterine infection rates were 6/11. In contrast, 22 cases of pregnant women with HBeAg negative, HBV-DNA were detected lowly-loaded and intrauterine infection rates were 2/22 (P < 0.01). Intrauterine infection rates of HBV in pregnant women with HBsAg-positive were 24.2% (8/33).
CONCLUSIONHBV infective rates in pregnant women in the local region were low. Pregnant women with serum HBeAg positive and HBV-DNA high-loaded were prone to intrauterine infection.
