Pregnant women hepatitis B markers investigation and analysis of intrauterine infection

VernacularTitle:孕妇乙型肝炎标志物调查和宫内感染分析
Author: Hui-Fen LU ¹ ; Wen-Jun JIN ; Xiao-Hong HUANG ; Qin-Ying ZHAO ; Hua-Ying MAO
Author Information

1. 浙江省湖州市中心医院
Keywords: Hepatitis B virus; Biological markers; Diseases transmission,vertieal
From: Chinese Journal of Experimental and Clinical Virology 2009;23(3):235-237
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between the hepatitis B virus (HBV) infection in pregnant women and intrauterine infection in local region. Methods The markers of hepatitis B (HBVM) were determined by time-resolved fluoroimmunoassay and HBV-DNA were determined by FQ-PCR. Results A total of 1262 pregnant women were examined the HBVM, 2.6%, 38.2%, 0.9%, 22.6%, 23.1% subjects were identified HBsAg, HBsAb, HBeAg, HBeAb, HBeAb positive respectively. In 33 eases of serum HBsAg-positive pregnant women, HBV-DNA were observed in most of 11 cases of pregnant women with HBeAg-positive and intrauterine infection rates were 6/11. In contrast, 22 cases of pregnant women with HBeAg negative, HBV-DNA were detected lowly-loaded and intrauterine infection rates were 2/22 (P < 0.01). Intrauterine infection rates of HBV in pregnant women with HBsAg-positive were 24.2% (8/33).Conclusion HBV infective rates in pregnant women in the local region were low. Pregnant women with serum HBeAg positive and HBV-DNA high-loaded were prone to intrauterine infection.