The relationship between the levels of HBV DNA loads and both the clinical characteristics and 48-week prognosis in patients with decompensated cirrhosis due to hepatitis B
10.3760/cma.j.issn.1003-9279.2009.04.014
- VernacularTitle:失代偿期乙肝肝硬化患者血清HBV DNA水平与临床特征及48周短期转归关系
- Author:
Qi-Huan XU
1
;
Yu-Sheng JIE
;
Shu-Zhen LIN
;
Xia SHU
;
Ni CHEN
;
Qi-Feng XIE
;
Gang LI
Author Information
1. 中山大学附属第三医院
- Keywords:
Hepatitis B virus;
Liver cirrhosis;
DNA;
Viral load
- From:
Chinese Journal of Experimental and Clinical Virology
2009;23(4):282-284
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between the levels of HBV DNA loads and beth the clinical characteristics and 48-week prognosis in patients with decompensated cirrhosis due to hepatitis B. Methods One hundred and forty-three patients with deeompensated cirrhosis of hepatitis B virus infection were divided into lowlevel HBV DNA group [HBV DNA < 105 copies/ml = (46 cases) and high-level HBV-DNA group(HBV DNA 105 copies/ml)(97 cases)]. 21 cases in low-level group and 52 cases in high-level group treated with nucleoside analog. Results There was no significant difference between the two groups on the demography and the baseline in ALT, ALB, TBil, CHE before treatment, while in AST and HBeAg were statistically different. At 48-week, there was no significant difference between the two groups on the liver function. The mortality rate in low-level group was similar to that in high level group. In the low-level HBV DNA patients, hepatocellular carcinoma, spontaneous peritonitis and gnstrointestiual hemorrhage were higer than that in the high-level HBV DNA patients. Conclusion In patients with decompensated cirrhosis due to hepatitis B, those who were in low-level HBV DNA had not got better than that in high-level HBV DNA, which indicated that earlier treatment was also needed in low-level HBV DNA patients.
