Evaluation of detection of Epstein-Barr virus Rta/IgG in nasopharyngeal carcinoma.
- Author:
Yu-Ming ZHENG
1
;
Yong-Lin CAIN
;
Ji-Ru CHENG
;
Jun LI
;
Yong-Kun MO
;
Jian-Quan GAO
;
Zhi-Rong DONG
;
Qing-Yan ZHONG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Viral; blood; Carcinoma; blood; diagnosis; immunology; virology; Case-Control Studies; Child; Diagnostic Tests, Routine; methods; Epstein-Barr Virus Infections; blood; diagnosis; immunology; virology; Female; Herpesvirus 4, Human; immunology; isolation & purification; Humans; Immediate-Early Proteins; blood; immunology; Immunoglobulin G; blood; Male; Middle Aged; Nasopharyngeal Neoplasms; blood; diagnosis; immunology; virology; Trans-Activators; blood; immunology; Young Adult
- From: Chinese Journal of Experimental and Clinical Virology 2009;23(4):285-287
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThis study was aimed to investigate the clinical value of Epstein-Barr virus (EBV) Rta/IgG in the diagnosis of nasopharyngeal carcinoma (NPC).
METHODSSerum samples derived from 211 untreated patients with NPC, 413 subjects including 203 non-NPC ENT patients and 210 healthy volunteers as control were examined for the presence of antibodies directed against Rta/IgG by using enzyme-linked immnunosorbent assay (ELISA). Receiver operating characteristic (ROC) curve was applied to perform methodical evaluation of this tumor marker.
RESULTSThe rA value median of Rta/IgG in NPC group was significantly higher than one in control group (P < 0.001). The area under ROC was 0.933. The sensitivity and specificity of this marker were 90.5% and 90.1%, respectively, when the best cutoff value was defined.
CONCLUSIONRta/IgG detected with ELISA method is a new target of EBV, and may be one of important marker for NPC diagnosis.
