Evaluation of detection of Epstein-Barr virus Rta/IgG in nasopharyngeal carcinoma

VernacularTitle:鼻咽癌EB病毒Rta/IgG抗体检测的诊断价值
Author: Yu-Ming ZHENG ¹ ; Yong-Lin CAI ; Ji-Ru CHENG ; Jun LI ; Yong-Kun MO ; Jian-Quan GAO ; Zhi-Rong DONG ; Qing-Yan ZHONG
Author Information

1. 广西梧州市红十字会医院
Keywords: Nasopharyngeal neoplasms; Herpesvirus 4; human; Antibodies; neoplasms
From: Chinese Journal of Experimental and Clinical Virology 2009;23(4):285-287
CountryChina
Language:Chinese
Abstract: Objective This study was aimed to investigate the clinical value of Epstein-Barr virus (EBV) Rta/IgG in the diagnosis of ansepharyngeal carcinoma (NPC). Methods Serum samples derived from 211 untreated patients with NPC, 413 subjects including 203 non-NPC ENT patients and 210 healthy volunteers as control were examined for the presence of antibodies directed against Rts/IgG by using enzyme-linked immnunosorbent assay (ELISA). Receiver operating characteristic (ROC) curve was applied to perform methodical evaluation of this tumor marker. Results The rA value median of Rta/IgG in NPC group was significantly higher than one in control group (P < 0.001). The area under ROC was 0.933. The sensitivity and specificity of this marker were 90.5% and 90.1%, respectively, when the best cutoff value was defined. Conclusion Rta/IgG detected with ELISA method is a new target of EBV, and may be one of important marker for NPC diagnosis.