The significance of HPV-DNA Genotyping assays in the ASC
10.3760/cma.j.issn.1003-9279.2009.04.018
- VernacularTitle:HPV-DNA分型检测在不同类型的ASC中的意义
- Author:
Hui BI
1
;
Jian ZHAO
;
Ke-Min LI
;
Qin-Ping LIAO
Author Information
1. 北京大学第一医院
- Keywords:
Neoplasms;
squamona cell;
Papilloma virus;
human;
Hybridization;
Cervical intraepithelial neoplasia;
Colposcopy
- From:
Chinese Journal of Experimental and Clinical Virology
2009;23(4):296-298
- CountryChina
- Language:Chinese
-
Abstract:
Objective To disscusa different outcomes of ASC-UC and ASC-H, two subtypes of ASC, and the significance of HPV-DNA genotyping assays in these two subtypes. Methods We reviewed and analyzed colposcopic and biopsy results of 1256 cases of ASC between Jan. 2005 to Dec. 2007, of which 580 cases have results of HPV-DNA genotyping assays. Results In 1256 ASC cases, ASC-US and ASC-H cases account for 90.1% and 9.9% respectively,CIN2 and higher levels diagnosed via colposcopy and cervical biopsy are 8.5% and24.2% respectively(P = 0.000). In ASC-US cases, the infection rate of HPV-DNA high risk types is 67.2%, there is statistic significance among different HPV-DNA results and biopsy pathology (P = 0.000). In ASC-H cases, the infection rate of HPV-DNA high risk types is 47.3%, there is no statistic significance among them (P = 0.054). Conclusion The clinical outcomes of ASC-US and ASC-H are different, we should distinguish and treat. HPV-DNA geantypiag assay is available in ASC-US triage, but Colposcopy is proposed for all ASC-H patients.
