Study on the association between chronic hepatitis B cirrhosis and HLA-DRB1 * 1301,1302 allele.

Author: Hong-Xia LIANG ¹ ; Zu-Jiang YU ; He-Qing JIANG
Author Information

1. Department of Infectious Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Publication Type:Journal Article
MeSH: Adult; Alleles; Female; HLA-DR Antigens; genetics; HLA-DRB1 Chains; Hepatitis B, Chronic; genetics; Humans; Liver Cirrhosis; genetics; Male
From: Chinese Journal of Experimental and Clinical Virology 2009;23(4):302-303
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the association between the chronic hepatitis B cirrhosis and HLA-DRB1 * 1301,1302 gene.
METHODSHLA-DRB1 * 1301,1302 allele in 27 patients with chronic hepatitis B cirrhosis and 30 patients with chronic hepatitis B was analyzed by using the polymerase chain reaction/sequence specific primer (PCR-SSP) technique.
RESULTSThe frenquency of HLA-DRB1 * 1301,1302 allele in the chronic hepatitis B cirrhosis group was markly higher than that in the chronic hepatitis B group.
CONCLUSIONHLA-DRB1 * 1301,1302 is closely associated with the suseptibility to chronic hepatitis cirrhosis.