Study on the association between chronic hepatitis B cirrhosis and HLA-DRB1*1301,1302 allele
10.3760/cma.j.issn.1003-9279.2009.04.020
- VernacularTitle:乙型肝炎肝硬化与HLA-DRB1*1301,1302等位基因的相关性研究
- Author:
Hong-Xia LIANG
1
;
Zu-Jiang YU
;
He-Qing JIANG
Author Information
1. 郑州大学附属第一医院
- Keywords:
Hepatitis B;
chronic;
Liver cirrhosis;
Polymerase chain reaction;
Genes MHC Ⅱ
- From:
Chinese Journal of Experimental and Clinical Virology
2009;23(4):302-303
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between the chronic hepatitis B cirrhosis and HLA-DRB1 * 1301,1302 gene. Methods HLA-DRB1* 1301,1302 allele in 27 patients with chronic hepatitis B cirrhosis and 30 patients with chronic hepatitis B was analyzed by using the polymerase chain reaction/sequence specific primer(PCR-SSP) technique. Results The frenquency of HLA-DRB1 * 1301,1302 allele in the chronic hepatitis B cirrhosis group was markly higher than that in the chronic hepatitis B group. Conclusion HLA-DRB1 * 1301,1302 is closely associated with the suseptibility to chronic hepatitis cirrhosis.
