Relations between ALT level and count of HBV special CTL and non-specific CTL in patients with chronic hepatitis B.
- Author:
Xi-bin GU
1
;
Xiao-juan YANG
;
Dong WANG
;
Zhong HUA
;
Hang-yuan WU
;
Yue-qin XU
;
Zhong-hua LU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Alanine Transaminase; metabolism; Female; Hepatitis B virus; genetics; immunology; physiology; Hepatitis B, Chronic; enzymology; immunology; virology; Humans; Lymphocyte Count; Male; T-Lymphocytes, Cytotoxic; immunology; Virus Replication; Young Adult
- From: Chinese Journal of Experimental and Clinical Virology 2009;23(5):343-345
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore relations between ALT level and hepatitis B virus (HBV) specific CTL and non-specific CTL in patients with chronic hepatitis B (CHB).
METHODS148 cases of CHB were divided into three groups according to ALT level. 35 cases in group A, ALT > or =2 x upper limit of normal value (ULN)--5 x ULN (100-250 IU/L); 53 cases in group B, ALT > 5 x ULN-- < or =10 x ULN (251-500 IU/L); 60 cases in group C, ALT > 10 x ULN ( > 500 IU/L). Flow cytometry is used to determine non-specific CTV. HBV specific CTL was tested on 74 cases of CHB (17 in group A, 27 in group B and 30 in group C) with positive (HLA)-A2. Compare HBV specific CTL, non-specific CTL, HBV DNA levels and positive rate of HBeAg.
RESULTSHBV specific CTL: Group A (0.42 +/- 0.10)% is higher than group B (0.25 +/- 0.08)%, t = 6.37, P < 0.01, group B is higher than group C (0.17 +/- 0.004)%, t = 5.14, P < 0.01; Non-specific CTL: Group A (15.01 +/- 3.01)% is lower than group B (18.1 +/- 5.02)%, t = 2.81, P < 0.01, group B is lower than group C (21.5 +/- 6.11)%, t = 3.07, P < 0.01; HBV DNA level: Group A [(4.97 +/- 0.86) log10 copies/ml] is lower than group B [(5.92 +/- 0.92) log10 copies/ml], t = 4.87, P < 0.01. Group B is lower than group C [(6.37 +/- 0.71) log10 copies/ml], t = 2.92, P < 0.01; Positive HBeAg: Group A (15 cases, 42.86%) is lower than group B (32 cases, 60.38%), chi2 = 2.59, P > 0.05. Group B is lower than group C (41 cases, 68.33%), chi2 = 0.78, P > 0.05. Group A is lower than group C, chi2 = 5.929, P < 0.05.
CONCLUSIONThe higher the non-specific CTL of patients with CHB is, the higher the ALT level would be, whereas the lower the HBV specific CTL is, the stronger the HBV replication would be.
