Study on the antigenicity and HA1 gene characteristics of influenza A viruses during 2004-2008 year in China.
- Author:
Ye ZHANG
1
;
Xiang ZHAO
;
Wei-juan HUANG
;
Jun-feng GUO
;
He-jiang WEI
;
Yan-hui CHENG
;
Xin-wan LI
;
Xi-yan LI
;
Yuan-ji GUO
;
Yue-long SHU
Author Information
- Publication Type:Journal Article
- MeSH: Amino Acid Sequence; Animals; Antigenic Variation; Cell Line; China; epidemiology; Dogs; Hemagglutinin Glycoproteins, Influenza Virus; chemistry; genetics; immunology; Humans; Influenza A Virus, H1N1 Subtype; chemistry; classification; genetics; immunology; Influenza A Virus, H3N2 Subtype; chemistry; classification; genetics; immunology; Influenza, Human; epidemiology; virology; Molecular Sequence Data; Phylogeny; Sequence Alignment
- From: Chinese Journal of Experimental and Clinical Virology 2009;23(6):405-408
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo under stand influenza A viruses epidemic, antigenicity and genetic characteristics variation between the vaccine and Circulation strains during 2004-2008 year in China.
METHODSThe influenza A viruses (H1N1, H3N2) isolated from 2004-2008 year were under took antigenic and sequence analysis. Influenza A virus antigenicity and genetic characteristics were analyzed thought amino acid variation compassion of HA1 protein of influenza A virus isolates.
RESULTSThe antigenicity of influenza H1N1 subtype viruses isolated from 2004 to 2007 is very similar with vaccine strain A/New Caledonia/20/1999 (HIN1)-like virus. The influenza H1N1 viruses circulated in 2008 year had similar antigenic characteristics with A/Brisben/59/2007 (H1N1) which is component of influenza vaccines for northern hemisphere 2008-2009 year. The influenza H3N2 subtype viruses of 2004-2005 year had antigenic variation comparatively with vaccine strain A/Fujian/411/12002 (H3N2), The antigenicity of 2006-2007 H3N2 viruses and 2008 year's is A/Wiscansin/67/2006(H3N2) and A/ Brisben/10/2006(H3N2) respectively.
CONCLUSIONThere is change of influenza A viruses (H1N1, H3N2) antigenic and genetic characteristics during 2004-2008 in China.
