Study on the antigenicity and HA1 gene characteristics of influenza A viruses during 2004-2008 year in China
10.3760/cma.j.issn.1003-9279.2009.06.002
- VernacularTitle:2004-2008年我国流行的A型流感病毒抗原性及HA1基因特性的研究
- Author:
Ye ZHANG
1
;
Xiong ZHAO
;
Wei-Juan HUANG
;
Jun-Feng GUO
;
He-Jiang WEI
;
Yan-Hui CHENG
;
Xin-Wan LI
;
Xi-Yan LI
;
Yuan-Ji GUO
;
Yue-Long SHU
Author Information
1. 中国疾病预防控制中心病毒病预防控制所
- Keywords:
Influenza;
Influenza A virus;
Antigens;
Genes
- From:
Chinese Journal of Experimental and Clinical Virology
2009;23(6):405-408
- CountryChina
- Language:Chinese
-
Abstract:
Objective To under smnd influenza A viruses epidemic,antigenicity and genetic characteristics variation between the vaccine and Circulation strains during 2004-2008 year in China.Methods The influenza A viruses(H1N1,H3N2)isolated from 2004-2008 year were under took antigenic and sequence analysis.Influenza A virus antigenicity and genetic characteristics were analyzed thounght amino acid variation compassion of HA1 protein of influenza A virus isilates.Results The antigenicity of influenza H1N1 subtype viruses isolated from 2004 to 2007 is very similar with vaccine strain A/New Caledonia/20/1999(H1N1)-like virus.The influenza H1N1 viruses circulated in 2008 year had similar antigenic characteristics with A/Brisben/59/2007(H1N1)Which is component of influem vaccines for northern hemisphere 2008-2009 year.The influenza H3N2 subtype viruses of 2004-2005 year had antigenic variation comparatively with vaccine strain A/Fujian/411/12002(H3N2),The antigenicity of 2006-2007 H3N2 viruses and 2008 year's is A/Wiscansin/67/2006(H3N2)and A/Brisben/10/2006(H3N2)respectively.Conclusion There is change of influenza A viruses(H1N1,H3N2)antigenic and genetic characteristics during 2004-2008 in China.
