Association between HLA-DQA1 gene polymorphism and the outcomes of hepatitis B virus infection

VernacularTitle:HLA-DQA1基因多态性和HBV感染结局的关联
Author: Yun-Hao XUN ¹ ; Jian-Chun GUO ; Wei-Zhen SHI ; Jun-Ping SHI ; Chang-Ling LIU
Author Information

1. 杭州市第六人民医院
Keywords: Hepatitm B vires; HLA antigens; Polymorphism(Genetics); Genes
From: Chinese Journal of Experimental and Clinical Virology 2009;23(6):430-433
CountryChina
Language:Chinese
Abstract: Objective To investigate the association between HLA-DQA1 gene polymorphism and the outcomes of hepatitis B virus infection in Chinese Han population.Methods A total of 180 consecutive patients with biopsy-proven hepatitis B virus infection(120 patients with chronic hepatitis B and 60 patients with asymptomatic HBV cartier)and 60 subjects who resolved from HBV infection spontaneously were studied.Genotype of human leukocyte antigen(HLA)-DQA1 was detected by polymerase chain reaction sequence specific primer(PCR-SSP).Results (1)The frequency of HLA-DQA1*0201 allele in chronic hepatitis B group was significant higher than the frequency in resolved from HBV infection spontaneously group(38.3% vs 5.8%,P