Expression of peroxiredoxin III in cervical lesions.
- Author:
Lian-qin LI
1
;
Chun-ling CHEN
;
Ze-yi CAO
;
Qin-ping LIAO
;
Hai-jun DU
;
Shao-bing ZHAN
;
Ling ZHOU
;
Yi ZENG
Author Information
- Publication Type:Journal Article
- MeSH: Cervix Uteri; metabolism; Female; Gene Expression Regulation, Neoplastic; Human papillomavirus 16; genetics; metabolism; Humans; Middle Aged; Oncogene Proteins, Viral; genetics; metabolism; Papillomavirus E7 Proteins; genetics; metabolism; Peroxiredoxins; genetics; metabolism; Repressor Proteins; genetics; metabolism; Up-Regulation; Uterine Cervical Neoplasms; genetics; metabolism; virology
- From: Chinese Journal of Experimental and Clinical Virology 2009;23(6):443-445
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression feature of peroxiredoxin III in cervical lesions and to further understand the mechanism for cervical cancer development/progression.
METHODSExpression of peroxiredoxin III was immunohistochemically detected in cervical cancer. In addition, cervical epithelia were transfected with recombinant adeno-associated virus vector containing human papillomavirus 16 E6/E7 and peroxiredoxin III expression was detected by quantitative real time PCR and Western blotting.
RESULTSPeroxiredoxin III was significantly up-regulated in cervical cancer tissues. Nevertheless, expression of peroxiredoxin III remained unchanged in cervical epithelial cells after transfection.
CONCLUSIONIt seems that Prx III is not related to cervical cancer initiation. Up-regulation of peroxiredoxin III in cervical cancer might be an active response to oxidative stress in malignant cells, which protects against oxidatiton-induced apoptosis.
