Expression of peroxiredoxin Ⅲ in cervical lesions
10.3760/cma.j.issn.1003-9279.2009.06.014
- VernacularTitle:过氧化物还原酶3在宫颈病变中的表达特点
- Author:
Lian-Qin LI
1
;
Chun-Ling CHEN
;
Ze-Ri CAO
;
Qin-Ping LIAO
;
Hai-Jun DU
;
Shao-Bing ZHAN
;
Ling ZHOU
;
Yi ZENG
Author Information
1. 清华大学附属第二医院
- Keywords:
Peroxides;
Cervix diseases;
Papillomavirus;
human;
Dependovixus;
Reactive oxygen species
- From:
Chinese Journal of Experimental and Clinical Virology
2009;23(6):443-445
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression feature of peroxiredoxin Ⅲ in cervical lesions and to further understand the mechanism for cervical cancer development/progression.Methods Expression of peroxiredoxin Ⅲ was immunohistochemically detected in cervical cancer.In addition.cervical epithelia were transfected with recombinant adeno-associated virus vector containing human papillomavirus 16 E6/E7 and pemxiredoxin Ⅲ expression was detected by quantitative real time PCR and Westem blotting.Results Peroxiredoxin Ⅲ was significantly up-regulated in cervical cancer tissues.Nevertheless,expression of peroxiredoxin Ⅲ remained unchanged in cervical epitllelial cells after transfection.Conclusion It seems that Prx Ⅲ is not related to cervical cancer initiation. Up-regulation of peroxiredoxin Ⅲ in cervical cancer might be an active response to oxidative stress in malignant cells,which protects against oxidatiton-induced apoptosis.
