The neuromuscular transmission effects induced by pralidoxine chloride on rats with acute isocarbophos poisoning.
- Author:
Zhichang JU
1
;
Jinxiu SUN
Author Information
- Publication Type:Journal Article
- MeSH: Acute Disease; Animals; Antidotes; pharmacology; Cholinesterase Inhibitors; poisoning; Insecticides; poisoning; Malathion; poisoning; Neuromuscular Junction; drug effects; physiology; Pralidoxime Compounds; pharmacology; Rats; Synaptic Transmission; drug effects
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2002;20(6):425-426
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of improving the neuromuscular transmission (NMT), "non-AChE-reactivating effects", by oximes in treating acute isocarbophos poisoning.
METHODSThe effect of pralidoxime chloride(PAM-Cl) on the neuromuscular transmission(NMT) in rats exposed to isocarbophos was studied by using the stimulation single fiber electromyography (SSFEMG) to determine the single fiber action potential.
RESULTSAfter the rats exposed to isocarbophos were treated by PAM-Cl, the mean consecutive difference(MCD) value [(25.99 +/- 5.84) microsecond] of single fiber action potential was significantly lower than that before PAM-Cl treatment [(33.21 +/- 4.09) microsecond, (P < 0.01)], but no AChE reactivation in blood and gastrocnemius was observed.
CONCLUSIONPAM-Cl has "non-AChE-reactivating effects", it could markedly improve isocarbophos-induced NMT block of gastrocnemius.
