Comparison and improvement in the methods of establishing animals model of experimental chronic sinusitis in rabbits.
- Author:
Bin LIN
1
;
Hui-Ge WANG
;
Xin-Qiang LIN
;
Xiao-Fen LIU
;
Yuan-Chun HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Chronic Disease; Disease Models, Animal; Rabbits; Sinusitis; microbiology
- From: Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2005;40(5):343-346
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare and improve the methods of establishing animal model of experimental chronic sinusitis in rabbits .
METHODSSixty-six New Zealand white rabbits were divided into seven groups: control group, sham-operation group I, sham-operation group II, bacteria inoculation group, ostia-blocked group, ostia-blocked and bacteria inoculation group, incomplete ostium blocked and set-cotton group. The animals were examined by the methods of histology and bacteriology after 42 days.
RESULTSThe positive rate of chronic inflammation in ostium blocked group was 80%, inoculated staphylococcus group was 100%, incomplete ostium blocked and set-cotton group was 100%, and the other groups were 0%. All infected sinuses displayed signs of moderate or severe chronic inflammation. The cultivated bacteria were mainly opportunistic pathogens. The probability of having abscess in maxillary sinus was high in ostia-blocked and bacteria inoculation group.
CONCLUSIONSThe method of incomplete ostium blockage and set cotton can establish stable chronic sinusitis model, it is a simple and perfect method.
