Relationship of MPO and NQO1 gene polymorphisms with susceptibility to acute leukemia.
- Author:
Ming-Feng JIA
1
;
Ya-Ming XI
;
Xiu-E SHI
;
Hao ZHANG
;
Wei DENG
;
Ming LI
;
Pei LI
;
Jian-Wang XU
;
Hai-Zhen MA
;
Xiao-Jian YAO
Author Information
1. Institute of Hematology and Department of Hematology, The First Clinical Hospital, Lanzhou University, Lanzhou 730000, Gansu Province, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Case-Control Studies;
Child;
Child, Preschool;
Female;
Genetic Predisposition to Disease;
Genotype;
Humans;
Leukemia;
genetics;
Male;
Middle Aged;
NAD(P)H Dehydrogenase (Quinone);
genetics;
Peroxidase;
genetics;
Young Adult
- From:
Journal of Experimental Hematology
2012;20(6):1336-1340
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study was to investigate the relationship of the gene polymorphisms of myeloperoxidase (MPO) and NAD (P) H: quinone oxidoreductase 1 (NQO1) with the susceptibility to acute leukemia (AL) in Chinese Gansu population. A 1:1 paired case-control study of 150 patients with acute leukemia and 150 cancer-free inpatients as a control was conducted to detect the polymorphisms of MPO and NQO1 by LDR techniques. The results showed that the MPO-463A genotype frequency in patient group was lower than that in control group, and there was significant difference of MPO (G-463A) genotype between patient group and control group (χ(2) = 11.828, P < 0.05, OR = 0.368, 95%CI = 0.205 - 0.610). The NQO1-609T genotype frequency in patient group was higher than that in control group, and there was significant difference of NQO1 (C-609T) genotype between patient group and control group (χ(2) = 17.931, P < 0.05, OR = 1.428, 95%CI = 1.237 - 3.339). The combined gene analysis showed that the AML risk in patients carrying the wild genotypes of MPO and NQO1 was dropped to 33.6%. It is concluded that the MPO and NQO1 gene polymorphisms are associated with susceptibility to AL. The AL risk may decrease in patients carrying MPO (G-463A) mutant gene (GA/AA), while the AL risk may increase in patients carrying NQO1 (C-609T) mutant gene (TC/TT). The combined effect of MPO and NQO1 wild genotypes may further decrease AL risk.
